Stringent regulation of DNA repair during human hematopoietic differentiation: a gene expression and functional analysis.

@article{Bracker2006StringentRO,
  title={Stringent regulation of DNA repair during human hematopoietic differentiation: a gene expression and functional analysis.},
  author={Tomke Ute Bracker and Bernd Giebel and Jan Spanholtz and Ursula R Sorg and Ludger Klein-Hitpass and Thomas Moritz and Juergen Thomale},
  journal={Stem cells},
  year={2006},
  volume={24 3},
  pages={722-30}
}
For the lymphohematopoietic system, maturation-dependent alterations in DNA repair function have been demonstrated. Because little information is available on the regulatory mechanisms underlying these changes, we have correlated the expression of DNA damage response genes and the functional repair capacity of cells at distinct stages of human hematopoietic differentiation. Comparing fractions of mature (CD34-), progenitor (CD34+ 38+), and stem cells (CD34+ 38-) isolated from umbilical cord… CONTINUE READING
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