Stringent Specificity in the Construction of a GABAergic Presynaptic Inhibitory Circuit

  title={Stringent Specificity in the Construction of a GABAergic Presynaptic Inhibitory Circuit},
  author={J. Nicholas Betley and Christopher V.E. Wright and Yoshiya Kawaguchi and Ferenc Erd{\'e}lyi and G{\'a}bor Szab{\'o} and Thomas M. Jessell and Julia A. Kaltschmidt},
GABAergic interneurons are key elements in neural coding, but the mechanisms that assemble inhibitory circuits remain unclear. In the spinal cord, the transfer of sensory signals to motor neurons is filtered by GABAergic interneurons that act presynaptically to inhibit sensory transmitter release and postsynaptically to inhibit motor neuron excitability. We show here that the connectivity and synaptic differentiation of GABAergic interneurons that mediate presynaptic inhibition is directed by… CONTINUE READING
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