Stringent Specificity in the Construction of a GABAergic Presynaptic Inhibitory Circuit

@article{Betley2009StringentSI,
  title={Stringent Specificity in the Construction of a GABAergic Presynaptic Inhibitory Circuit},
  author={J. Nicholas Betley and Christopher V.E. Wright and Yoshiya Kawaguchi and Ferenc Erd{\'e}lyi and G{\'a}bor Szab{\'o} and Thomas M. Jessell and Julia A. Kaltschmidt},
  journal={Cell},
  year={2009},
  volume={139},
  pages={161-174}
}
GABAergic interneurons are key elements in neural coding, but the mechanisms that assemble inhibitory circuits remain unclear. In the spinal cord, the transfer of sensory signals to motor neurons is filtered by GABAergic interneurons that act presynaptically to inhibit sensory transmitter release and postsynaptically to inhibit motor neuron excitability. We show here that the connectivity and synaptic differentiation of GABAergic interneurons that mediate presynaptic inhibition is directed by… CONTINUE READING
Highly Influential
This paper has highly influenced 11 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
82 Citations
55 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 82 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 55 references

A combination of three distinct trafficking signals mediates axonal targeting and presynaptic clustering of GAD65

  • J. Kanaani, D. el-Husseini Ael, A. Aguilera-Moreno, J. M. Diacovo, D. S. Bredt, S. Baekkeskov
  • J. Cell Biol
  • 2002
Highly Influential
4 Excerpts

Molecular mechanisms of target specificity during synapse formation

  • K. Shen
  • Curr. Opin. Neurobiol
  • 2004
Highly Influential
4 Excerpts

Similar Papers

Loading similar papers…