String Kernels of Imperfect Matches for Off-target Detection in RNA Interference

  title={String Kernels of Imperfect Matches for Off-target Detection in RNA Interference},
  author={Shibin Qiu and T. Lane},
  booktitle={International Conference on Computational Science},
  • Shibin Qiu, T. Lane
  • Published in
    International Conference on…
    22 May 2005
  • Computer Science
RNA interference (RNAi) is a posttranscriptional gene silencing mechanism frequently used to study gene functions and knock down viral genes. RNAi has been regarded as a highly effective means of gene repression. However, an “off-target effect” deteriorates its specificity and applicability. The complete off-target effects can only be characterized by examining all factors through systematic investigation of each gene in a genome. However, this complete investigation is too expensive to conduct… Expand
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