Striking deposition of toxic eosinophil major basic protein in mucus: implications for chronic rhinosinusitis.

@article{Ponikau2005StrikingDO,
  title={Striking deposition of toxic eosinophil major basic protein in mucus: implications for chronic rhinosinusitis.},
  author={J. Ponikau and D. Sherris and G. Kephart and E. Kern and D. Congdon and C. Adolphson and M. Springett and G. Gleich and H. Kita},
  journal={The Journal of allergy and clinical immunology},
  year={2005},
  volume={116 2},
  pages={
          362-9
        }
}
BACKGROUND The mechanisms by which eosinophilic inflammation damages the epithelium and contributes to recurrent acute exacerbations in chronic rhinosinusitis (CRS) have not been fully elucidated. OBJECTIVE We tested the hypotheses that eosinophils deposit toxic major basic protein (MBP) in the mucus and that MBP reaches concentrations able to damage the sinonasal epithelium. METHODS Tissue specimens with mucus attached to the tissue were carefully collected from 22 patients with CRS and… Expand
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