Strict regulation of CAIXG250/MN by HIF-1α in clear cell renal cell carcinoma

@article{Grabmaier2004StrictRO,
  title={Strict regulation of CAIXG250/MN by HIF-1α in clear cell renal cell carcinoma},
  author={Karin Grabmaier and Mirjam CA de Weijert and Gerald W Verhaegh and Jack A Schalken and Egbert Oosterwijk},
  journal={Oncogene},
  year={2004},
  volume={23},
  pages={5624-5631}
}
Renal cell carcinoma of the clear cell type (ccRCC) is associated with loss of functional von Hippel–Lindau (VHL) protein and high, homogeneous expression of the G250MN protein, an isoenzyme of the carbonic anhydrase family. High expression of G250MN is found in all ccRCCs, but not in most normal tissues, including normal human kidney. We specifically studied the mechanism of transcriptional regulation of the CAIXG250 gene in RCC. Previous studies identified Sp1 and hypoxia-inducible factor… CONTINUE READING

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