Striatin assembles a membrane signaling complex necessary for rapid, nongenomic activation of endothelial NO synthase by estrogen receptor alpha.

@article{Lu2004StriatinAA,
  title={Striatin assembles a membrane signaling complex necessary for rapid, nongenomic activation of endothelial NO synthase by estrogen receptor alpha.},
  author={Qing Lu and David C. Pallas and Howard K. Surks and W. Baur and Michael E. Mendelsohn and Richard H Karas},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2004},
  volume={101 49},
  pages={17126-31}
}
Steroid hormone receptors (SHRs) are ligand-activated transcription factors that regulate gene expression. SHRs also mediate rapid, nongenomic cellular activation by steroids. In vascular endothelial cells, the SHR for estrogen, estrogen receptor (ER) alpha, is targeted by unknown mechanisms to a functional signaling module in membrane caveolae that enables estrogen to rapidly activate the mitogen-activated protein kinase and phosphatidylinositol 3-Akt kinase pathways, and endothelial NO… CONTINUE READING