Striated muscle-specific beta(1D)-integrin and FAK are involved in cardiac myocyte hypertrophic response pathway.

@article{Pham2000StriatedMB,
  title={Striated muscle-specific beta(1D)-integrin and FAK are involved in cardiac myocyte hypertrophic response pathway.},
  author={Can G. Pham and Alice E Harpf and Rebecca S. Keller and Hien Thi Vu and Shaw Yung Shai and Joseph C. Loftus and Robert S. Ross},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2000},
  volume={279 6},
  pages={
          H2916-26
        }
}
  • C. Pham, A. Harpf, +4 authors R. Ross
  • Published 1 December 2000
  • Biology
  • American journal of physiology. Heart and circulatory physiology
Alterations in the extracellular matrix occur during the cardiac hypertrophic process. Because integrins mediate cell-matrix adhesion and beta(1D)-integrin (beta1D) is expressed exclusively in cardiac and skeletal muscle, we hypothesized that beta1D and focal adhesion kinase (FAK), a proximal integrin-signaling molecule, are involved in cardiac growth. With the use of cultured ventricular myocytes and myocardial tissue, we found the following: 1) beta1D protein expression was upregulated… 
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