Striated muscle-specific beta(1D)-integrin and FAK are involved in cardiac myocyte hypertrophic response pathway.

@article{Pham2000StriatedMB,
  title={Striated muscle-specific beta(1D)-integrin and FAK are involved in cardiac myocyte hypertrophic response pathway.},
  author={Con Gia Pham and Alice E. Harpf and Rebecca S. Keller and Huong Thi Thu Vu and Shrot Shai and Joseph C. Loftus and Robert S Ross},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2000},
  volume={279 6},
  pages={H2916-26}
}
Alterations in the extracellular matrix occur during the cardiac hypertrophic process. Because integrins mediate cell-matrix adhesion and beta(1D)-integrin (beta1D) is expressed exclusively in cardiac and skeletal muscle, we hypothesized that beta1D and focal adhesion kinase (FAK), a proximal integrin-signaling molecule, are involved in cardiac growth. With the use of cultured ventricular myocytes and myocardial tissue, we found the following: 1) beta1D protein expression was upregulated… CONTINUE READING

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