Striatal volume loss in HD as measured by MRI and the influence of CAG repeat.

@article{Rosas2001StriatalVL,
  title={Striatal volume loss in HD as measured by MRI and the influence of CAG repeat.},
  author={H. Diana Rosas and Jennifer S Goodman and Yin-Ching Iris Chen and Bruce G. Jenkins and David N. Kennedy and Nicolaos Makris and Monica Patti and Larry J. Seidman and Myron Flint Beal and Walter J. Koroshetz},
  journal={Neurology},
  year={2001},
  volume={57 6},
  pages={1025-8}
}
BACKGROUND Huntington's disease (HD) is an autosomal dominant neurodegenerative disease that results from the expansion of a trinucleotide (CAG) repeat on chromosome 4. Progressive degeneration of the striatum is the pathologic hallmark of the disease. Little is known about the regional selectivity of the neurodegeneration and its relationship to the genetic expansion. METHODS The authors used high-resolution MRI to determine the relationship between the genetic expansion and the degree of… CONTINUE READING