Striatal response to reward anticipation: evidence for a systems-level intermediate phenotype for schizophrenia.

@article{Grimm2014StriatalRT,
  title={Striatal response to reward anticipation: evidence for a systems-level intermediate phenotype for schizophrenia.},
  author={Oliver Grimm and Andreas Heinz and Henrik Walter and Peter Kirsch and Susanne Erk and Leila Haddad and Michael M. Plichta and Nina Romanczuk-Seiferth and Lydia P{\"o}hland and Sebastian Mohnke and Thomas W. M{\"u}hleisen and Manuel Mattheisen and Stephanie H. Witt and Axel Sch{\"a}fer and Sven Cichon and Markus M. N{\"o}then and Marcella Rietschel and Heike Tost and Andreas Meyer-Lindenberg},
  journal={JAMA psychiatry},
  year={2014},
  volume={71 5},
  pages={531-9}
}
IMPORTANCE Attenuated ventral striatal response during reward anticipation is a core feature of schizophrenia that is seen in prodromal, drug-naive, and chronic schizophrenic patients. Schizophrenia is highly heritable, raising the possibility that this phenotype is related to the genetic risk for the disorder. OBJECTIVE To examine a large sample of healthy first-degree relatives of schizophrenic patients and compare their neural responses to reward anticipation with those of carefully… CONTINUE READING

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