Striatal potassium channel dysfunction in Huntington's disease transgenic mice.

@article{Ariano2005StriatalPC,
  title={Striatal potassium channel dysfunction in Huntington's disease transgenic mice.},
  author={Marjorie A. Ariano and Carlos Cepeda and Christopher R. Calvert and Jorge Flores-Hern{\'a}ndez and Elizabeth Hern{\'a}ndez-Echeagaray and Gloria J. Klapstein and Scott H. Chandler and Neil Aronin and Marian Difiglia and Michael S Levine},
  journal={Journal of neurophysiology},
  year={2005},
  volume={93 5},
  pages={2565-74}
}
Huntington's disease (HD) is a neurodegenerative disorder that mainly affects the projection neurons of the striatum and cerebral cortex. Genetic mouse models of HD have shown that neurons susceptible to the mutation exhibit morphological and electrophysiological dysfunctions before and during development of the behavioral phenotype. We used HD transgenic mouse models to examine inwardly and outwardly rectifying K+ conductances, as well as expression of some related K+ channel subunits… CONTINUE READING