Striatal muscarinic receptor antagonism reduces 24-h food intake in association with decreased preproenkephalin gene expression.

@article{Pratt2005StriatalMR,
  title={Striatal muscarinic receptor antagonism reduces 24-h food intake in association with decreased preproenkephalin gene expression.},
  author={Wayne E. Pratt and Ann E. Kelley},
  journal={The European journal of neuroscience},
  year={2005},
  volume={22 12},
  pages={
          3229-40
        }
}
Cholinergic interneurons of the striatum respond to motivationally relevant stimuli and are involved in appetitive learning. However, there has been relatively little inquiry into the role of striatal acetylcholine in food motivation. Here we show in rats that a single infusion of the muscarinic receptor antagonist scopolamine (0, 5.0 or 10.0 microg/0.5 microL bilaterally) potently reduced 24-h food intake following injections into either the ventral or dorsal striatum, without affecting water… CONTINUE READING
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