Striatal metabotropic glutamate receptors as a target for pharmacotherapy in Parkinson’s disease

@article{Bonsi2006StriatalMG,
  title={Striatal metabotropic glutamate receptors as a target for pharmacotherapy in Parkinson’s disease},
  author={Paola Bonsi and Dario Cuomo and Barbara Picconi and Giuseppe Sciamanna and Anne Tscherter and Martin Tolu and Giorgio Bernardi and Paolo Calabresi and Antonio Pisani},
  journal={Amino Acids},
  year={2006},
  volume={32},
  pages={189-195}
}
Parkinson’s disease (PD) is a common neurodegenerative disorder characterized by the loss of dopamine (DA)-containing neurons in the substantia nigra pars compacta (SNc). The symptoms are resting tremor, slowness of movement, rigidity and postural instability. Evidence that an imbalance between dopaminergic and cholinergic transmission takes place within the striatum led to the utilization of DA precursors, DA receptor agonists and anticholinergic drugs in the symptomatic therapy of PD. However… CONTINUE READING

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