Striatal mechanisms and pathogenesis of parkinsonian signs and motor complications.

@article{Chase2000StriatalMA,
  title={Striatal mechanisms and pathogenesis of parkinsonian signs and motor complications.},
  author={Thomas N. Chase and Justin D. Oh},
  journal={Annals of neurology},
  year={2000},
  volume={47 4 Suppl 1},
  pages={S122-9; discussion S129-30}
}
Recent studies suggest that motor dysfunction associated with the chronic nonphysiologic stimulation of dopaminergic receptors on striatal spiny neurons alters the sensitivity of nearby glutamatergic receptors, especially those of the N-methyl-D-aspartate (NMDA) subtype. Lesioning the nigrostriatal dopamine system of rats or nonhuman primates induces parkinsonian signs; subsequent once- or twice-daily treatment with levodopa produces many of the features of the human motor complication syndrome… CONTINUE READING