Striatal implantation of GDNF releasing biodegradable microspheres promotes recovery of motor function in a partial model of Parkinson's disease.

@article{Jollivet2004StriatalIO,
  title={Striatal implantation of GDNF releasing biodegradable microspheres promotes recovery of motor function in a partial model of Parkinson's disease.},
  author={Christophe Jollivet and Anne Aubert-Pouessel and Anne Clavreul and Marie Claire Venier-Julienne and S{\'e}verine R{\'e}my and Claudia N. Montero-Menei and Jean Pierre Benoit and Philippe Menei},
  journal={Biomaterials},
  year={2004},
  volume={25 5},
  pages={933-42}
}
The recent identification of neurotrophic factors, such as the glial cell line derived neurotrophic factor (GDNF), acting on mesencephalic dopaminergic neurons, offers the possibility to stimulate the axonal regeneration of these cells which are affected in Parkinson's disease. Nevertheless, a safe and efficient GDNF delivery system that may be used in clinical trials is still lacking. We have developed GDNF-releasing microspheres capable of releasing the neurotrophic factor for at least 2… CONTINUE READING