Striatal grafts in rats with unilateral neostriatal lesions--II. In vivo monitoring of GABA release in globus pallidus and substantia nigra.

@article{Sirinathsinghji1988StriatalGI,
  title={Striatal grafts in rats with unilateral neostriatal lesions--II. In vivo monitoring of GABA release in globus pallidus and substantia nigra.},
  author={Dalip J. S. Sirinathsinghji and Stephen B. Dunnett and O. Isacson and Deborah J. Clarke and Keith F. Kendrick and A. Bj{\"o}rklund},
  journal={Neuroscience},
  year={1988},
  volume={24 3},
  pages={803-11}
}
GABA release was recorded in vivo by push-pull perfusion from the globus pallidus and substantia nigra of control rats, rats with unilateral ibotenic acid lesions of the neostriatum, and rats with embryonic striatal tissue grafts implanted in the lesioned striatum. The lesions reduced baseline levels of GABA release to 5% of control levels in the globus pallidus and to 13% of control levels in the substantia nigra pars reticulata. GABA release was substantially restored in both the globus… CONTINUE READING

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