Striatal gene expression of RGS2 and RGS4 is specifically mediated by dopamine D1 and D2 receptors: clues for RGS2 and RGS4 functions.

@article{Taymans2003StriatalGE,
  title={Striatal gene expression of RGS2 and RGS4 is specifically mediated by dopamine D1 and D2 receptors: clues for RGS2 and RGS4 functions.},
  author={J. -M. Taymans and Jos{\'e}e E. Leysen and Xavier Langlois},
  journal={Journal of neurochemistry},
  year={2003},
  volume={84 5},
  pages={
          1118-27
        }
}
Of all partners involved in G-protein coupled receptor (GPCR) signalling, the regulator of G-protein signalling (RGS) proteins are the only ones showing fast gene expression changes after various stimuli. These expression changes can offer feedback regulation to GPCR signalling as RGS accelerate the return of G-proteins to their inactive form and exert regulatory functions on intracellular effectors. However, it is not yet known which RGS regulate which receptor transduction pathways in the… CONTINUE READING
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