Striatal dysfunction increases basal ganglia output during motor cortex activation in parkinsonian rats.

@article{Belluscio2007StriatalDI,
  title={Striatal dysfunction increases basal ganglia output during motor cortex activation in parkinsonian rats.},
  author={Mariano A. Belluscio and Luis A Riquelme and Mario Gustavo Murer},
  journal={The European journal of neuroscience},
  year={2007},
  volume={25 9},
  pages={2791-804}
}
During movement, inhibitory neurons in the basal ganglia output nuclei show complex modulations of firing, which are presumptively driven by corticostriatal and corticosubthalamic input. Reductions in discharge should facilitate movement by disinhibiting thalamic and brain stem nuclei while increases would do the opposite. A proposal that nigrostriatal dopamine pathway degeneration disrupts trans-striatal pathways' balance resulting in sustained overactivity of basal ganglia output nuclei… CONTINUE READING

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