Striatal dopamine uptake in the rat: in vivo analysis by fast cyclic voltammetry.

@article{Stamford1984StriatalDU,
  title={Striatal dopamine uptake in the rat: in vivo analysis by fast cyclic voltammetry.},
  author={Jonathan A. Stamford and Zygmunt L. Kruk and Julian Millar and R Mark Wightman},
  journal={Neuroscience letters},
  year={1984},
  volume={51 1},
  pages={133-8}
}
Electrical stimulation of the median forebrain bundle of the chloral hydrate anaesthetised rat evoked dopamine release in the ipsilateral striatum, which was monitored with fast cyclic voltammetry. On cessation of stimulation, the extracellular concentration of dopamine fell to sub-detectable levels over a period of about 15 s. This fall appeared to be due to a saturable, low affinity uptake system that could be inhibited by nomifensine (20 mg/kg i.p.). These experiments constitute the first… CONTINUE READING