Striatal dopamine transporter density in major depression

  title={Striatal dopamine transporter density in major depression},
  author={Teijamari Laasonen-Balk and Jyrki T. Kuikka and Heimo Viinam{\"a}ki and Minna Husso-Saastamoinen and J. Lehtonen and Jari Tiihonen},
Rationale: There are no previous data available regarding [123I]β-CIT binding to the dopamine transporter sites in the basal ganglia in depressed patients. Objective: The present study tested the hypothesis that the brain DAT density in depressed patients is lower than that in matched healthy controls. Methods: Fifteen drug-naive outpatients with major depression and 18 healthy controls were investigated using single photon emission computerized tomography (SPECT) with a high-affinity dopamine… 

Dopamine transporter density may be associated with the depressed affect in healthy subjects

These data suggest that 99mTc-TRODAT-1 binding affinity to DAT sites may be associated with depressive affect in healthy subjects, and supports prior observations of greater 99m Tc- TRODat-1 DVRs in patients with major depressive episode.

Greater availability of dopamine transporters in patients with major depression — A dual-isotope SPECT study

Greater striatal dopamine transporter density may be associated with major depressive episode.

Greater availability of brain dopamine transporters in major depression shown by [99m Tc]TRODAT-1 SPECT imaging.

Dopamine transporter affinity may be higher than normal in the basal ganglia of depressed patients, suggesting that dopamine function may be altered in depression and may also be a mechanism of antidepressant activity.

123I-β-CIT binding and recovery from depression

Abstract.Eighteen depressive outpatients were investigated using single-photon emission computerized tomography (SPECT) with a high-affinity dopamine (DA) and serotonin transporter (SERT) specific

A Preliminary Study of Dopamine Transporter Binding in Bipolar and Unipolar Depressed Patients and Healthy Controls

It is suggested that striatal DAT density may be increased in bipolar and unipolar depressed patients compared to controls, and thatipolar and un bipolar depressed patients may have a different pattern of striatalDAT binding.

Striatal dopamine D2 receptors in medication-naive patients with major depressive disorder as assessed with [11C]raclopride PET

The findings in this sample of treatment-seeking, drug-naive and predominantly first-episode patients with major depression do not support the involvement of striatal dopamine D2 receptors in the pathophysiology of the illness, but do not exclude the potential importance of dopaminergic mechanisms in antidepressant drug action.

Dopamine transporter availability in symptomatic depressed patients with seasonal affective disorder and healthy controls

These data suggest reductions in the availability of striatal DAT binding sites in untreated symptomatic depressed SAD patients, providing evidence that brain dopaminergic systems may be involved in the pathophysiology of SAD.



Clinical and psychometric correlates of dopamine D2 binding in depression

Increased IBZM binding in striatum probably reflects reduced dopamine function, whether due to reduced release of dopamine, or secondary up-regulation of receptors, as well as the possible role of medication as a confounding variable.

SPECT imaging of dopamine and serotonin transporters with [123I]β‐CIT: Pharmacological characterization of brain uptake in nonhuman primates

It is suggested that [123I]β‐CIT will be a useful SPECT tracer of DA and 5‐HT transporters in living human brain.

Altered striatal dopamine re-uptake site densities in habitually violent and non-violent alcoholics

The results indicate that both types of alcoholics have alterations in striatal dopaminergic system, though these occur in opposite directions.

Sex differences in the striatal dopamine D2 receptor binding characteristics in vivo.

The results confirm the age-related reduction of D2 receptor density and binding potential in both sexes in vivo and suggest an increased endogenous striatal dopamine concentration in women.

Depressive symptoms and presynaptic dopamine function in neuroleptic-naive schizophrenia

Dopamine D2 receptors in depression measured with single photon emission computed tomography

Hypoperfusion in the limbic system and prefrontal cortex in depression: SPECT with anatomic standardization technique.

  • H. ItoR. Kawashima H. Fukuda
  • Medicine, Psychology
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine
  • 1996
Investigation of CBF distribution abnormalities in depression using SPECT and an anatomic standardization technique found decreases in CBF in the prefrontal cortices, limbic systems and paralimbic areas may be related to impaired attention as well as cognitive and emotional responses.

Paralimbic hypoperfusion in unipolar depression.

These findings implicate selective dysfunction of paralimbic brain regions in clinically depressed patients, independent of their medication use, and support the concept of specific neural systems that regulate mood.

Regional cerebral blood flow alterations in unipolar depression

Cerebral perfusion correlates of depressed mood

World depression severity and an independent ‘vital’ depression factor were associated in subjects with increased perfusion in cingulate and other paralimbic areas and there was a probable association between an increase in an anxious-depression factor and reduced frontal neocortical perfusion.