Striatal dopamine metabolism in monoamine oxidase B-deficient mice: a brain dialysis study.

@article{Fornai1999StriatalDM,
  title={Striatal dopamine metabolism in monoamine oxidase B-deficient mice: a brain dialysis study.},
  author={Francesco Fornai and Kevin Chen and Fillippo Sean Giorgi and Marco Gesi and Maria Grazia Alessandr{\`i} and Jean Chen Shih},
  journal={Journal of neurochemistry},
  year={1999},
  volume={73 6},
  pages={2434-40}
}
We have studied striatal dopamine (DA) metabolism in monoamine oxidase (MAO) B-deficient mice using brain microdialysis. Baseline DA levels were similar in wild-type and knock-out (KO) mice. Administration of a selective MAO A inhibitor, clorgyline (2 mg/kg), increased DA levels and decreased levels of its metabolites in all mice, but a selective MAO B inhibitor, l-deprenyl (1 mg/ kg), had no effect. Administration of 10 and 50 mg/kg L-DOPA, the precursor of DA, increased the levels of DA… CONTINUE READING
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