Striatal dopamine deficiency in Parkinson's disease: role of aging.

@article{Scherman1989StriatalDD,
  title={Striatal dopamine deficiency in Parkinson's disease: role of aging.},
  author={Daniel Scherman and C Desnos and François Darchen and Pierre Pollak and France Javoy-Agid and Yves Agid},
  journal={Annals of neurology},
  year={1989},
  volume={26 4},
  pages={551-7}
}
The striatal dopaminergic innervation was investigated postmortem in 49 control and 57 parkinsonian brains by assessing the binding of tritiated alpha-dihydrotetrabenazine ([3H]TBZOH), a specific ligand of the vesicular monoamine transporter. The density of [3H]TBZOH binding sites in the caudate nucleus of control subjects decreased significantly with age, suggesting an age-dependent reduction in striatal dopamine innervation. In contrast, an increase with the age at time of death was observed… CONTINUE READING

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