Striatal dopamine D2/D3 receptor availability correlates with individual response characteristics to pain.

@article{Pertovaara2004StriatalDD,
  title={Striatal dopamine D2/D3 receptor availability correlates with individual response characteristics to pain.},
  author={Antti Pertovaara and Ilkka Kristian Martikainen and Nora Hagelberg and Heikki Mansikka and Kjell N{\aa}gren and Jarmo Hietala and Harry Scheinin},
  journal={The European journal of neuroscience},
  year={2004},
  volume={20 6},
  pages={1587-92}
}
We studied in healthy humans the contribution of cerebral dopamine D2/D3 receptors to individual differences in response characteristics to painful stimulation. Positron emission tomography was used to measure the dopamine D2/D3 binding potential (D2/D3 BP) with [(11)C]raclopride in the striatum (n = 8) and with [(11)C]FLB 457 in the extrastriatal regions (n = 11). Sensitivity to cutaneous heat pain was assessed by a traditional threshold method and by an analysis based on the signal detection… CONTINUE READING