Striatal dopamine D1-like receptor binding is unchanged in primary focal dystonia.

@article{Karimi2013StriatalDD,
  title={Striatal dopamine D1-like receptor binding is unchanged in primary focal dystonia.},
  author={Morvarid K Karimi and Stephen M. Moerlein and Tom O. Videen and Yi Su and Hubert Flores and Joel S. Perlmutter},
  journal={Movement disorders : official journal of the Movement Disorder Society},
  year={2013},
  volume={28 14},
  pages={2002-6}
}
BACKGROUND Multiple studies have demonstrated decreases in striatal D2-like (D2, D3) radioligand binding in primary focal dystonias. Although most investigations have focused on D2-specific receptors (D2R), a recent study suggests that the decreased D2-like binding may be due to a D3-specific (D3R) abnormality. However, only limited data exist on the role of D1-specific receptors (D1R) and the D1R-mediated pathways within basal ganglia in dystonia. Metabolic positron emission tomography (PET… CONTINUE READING
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