Striatal denervation pattern predicts levodopa effects on sequence learning in Parkinson's disease.

@article{Kwak2013StriatalDP,
  title={Striatal denervation pattern predicts levodopa effects on sequence learning in Parkinson's disease.},
  author={Youngbin Kwak and Nicolaas I. Bohnen and Martijn L. T. M. M{\"u}ller and Praveen Dayalu and Rachael D. Seidler},
  journal={Journal of motor behavior},
  year={2013},
  volume={45 5},
  pages={
          423-9
        }
}
Mild to moderate Parkinson's disease shows more denervation in the posterodorsal striatum and sparing of the anteroventral striatum. Dopaminergic medications can interfere with anteroventral striatum function by overdosing this relatively intact structure. The authors determined how regional striatal denervation affects medication-associated sequence learning impairment in Parkinson's disease. Eighteen Parkinson's patients performed motor sequence learning on and off levodopa. Patients… CONTINUE READING