Striatal astrocytes produce neuroblasts in an excitotoxic model of Huntington's disease.

Abstract

In the adult brain, subsets of astrocytic cells residing in well-defined neurogenic niches constitutively generate neurons throughout life. Brain lesions can stimulate neurogenesis in otherwise non-neurogenic regions, but whether local astrocytic cells generate neurons in these conditions is unresolved. Here, through genetic and viral lineage tracing in… (More)
DOI: 10.1242/dev.116657

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