Striatal Network Models of Huntington's Disease Dysfunction Phenotypes

  title={Striatal Network Models of Huntington's Disease Dysfunction Phenotypes},
  author={Pengsheng Zheng and J. Kozloski},
  journal={Frontiers in Computational Neuroscience},
We present a network model of striatum, which generates “winnerless” dynamics typical for a network of sparse, unidirectionally connected inhibitory units. We observe that these dynamics, while interesting and a good match to normal striatal electrophysiological recordings, are fragile. Specifically, we find that randomly initialized networks often show dynamics more resembling “winner-take-all,” and relate this “unhealthy” model activity to dysfunctional physiological and anatomical phenotypes… 

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