Striatal Dopaminergic and Serotonergic Markers in Human Heroin Users

  title={Striatal Dopaminergic and Serotonergic Markers in Human Heroin Users},
  author={Stephen J. Kish and Kathryn S. Kalasinsky and Peter Derkach and Gregory A. Schmunk and Mark Guttman and Lee Cyn Ang and Vernard I Adams and Yoshiaki Furukawa and John W Haycock},
To establish whether chronic opiate exposure might impair brain dopaminergic or serotonergic function in humans, we assessed biochemical indices of monoaminergic neurotransmitter activity and integrity in post mortem striatum of nine chronic heroin users and 14 control subjects. Striatal levels of the vesicular monoamine transporter were normal, suggesting that the density of dopamine nerve terminals is not reduced in heroin users. In nucleus accumbens, levels of tyrosine hydroxylase protein… CONTINUE READING


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