Striatal Akt/GSK3 signaling pathway in the development of L-Dopa-induced dyskinesias in MPTP monkeys

@article{Morissette2010StriatalAS,
  title={Striatal Akt/GSK3 signaling pathway in the development of L-Dopa-induced dyskinesias in MPTP monkeys},
  author={Marc P. Morissette and Pershia Samadi and Abdallah Hadj Tahar and Nancy B{\'e}langer and Th{\'e}r{\`e}se Di Paolo},
  journal={Progress in Neuro-Psychopharmacology and Biological Psychiatry},
  year={2010},
  volume={34},
  pages={446-454}
}
L-Dopa treatment, the gold standard therapy for Parkinson's disease, is hampered by motor complications such as dyskinesias. Recently, impairment of striatal Akt/GSK3 signaling was proposed to play a role in the mechanisms implicated in development of L-Dopa-induced dyskinesias in a rodent model of Parkinson's disease. The present experiment investigated in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) monkeys, the effects on Akt/GSK3 of chronic L-Dopa treatment inducing dyskinesias… CONTINUE READING

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Regulation of a protein phosphatase cascade allows convergent dopamine and glutamate signals to activate ERK in the striatum.

Proceedings of the National Academy of Sciences of the United States of America • 2005
View 13 Excerpts
Highly Influenced

Effect of a selective glutamate antagonist on L-dopa-induced dyskinesias in drug-naive parkinsonian monkeys

A Hadj Tahar, L Gregoire, +3 authors PJ. Bedard
Neurobiol Dis • 2004
View 4 Excerpts
Highly Influenced

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