Striatal A2A adenosine receptors differentially regulate spontaneous and K+-evoked glutamate release in vivo in young and aged rats.

@article{Corsi1999StriatalAA,
  title={Striatal A2A adenosine receptors differentially regulate spontaneous and K+-evoked glutamate release in vivo in young and aged rats.},
  author={Claudia Corsi and Alessia Melani and Loria Bianchi and Giancarlo Pepeu and Felicita Pedata},
  journal={Neuroreport},
  year={1999},
  volume={10 4},
  pages={
          687-91
        }
}
The effect of the adenosine A2A receptor agonist CGS 21680 on glutamate and aspartate release was investigated in the striatum of young and old rats by microdialysis experiments. CGS 21680 (10 microM) significantly increased glutamate and aspartate spontaneous outflow in young but not in old rats. On the contrary, CGS 21680 induced the same decrease in K+-evoked glutamate outflow in both young and aged rats. A lower dose of CGS 21680 (1 microM) failed to modify either spontaneous or K+-evoked… CONTINUE READING
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