Stretching single talin rod molecules activates vinculin binding.

  title={Stretching single talin rod molecules activates vinculin binding.},
  author={Armando del Rio and Raul Perez-Jimenez and Ruchuan Liu and Pere Roca-Cusachs and J. M. Fern{\'a}ndez and Michael P Sheetz},
  volume={323 5914},
The molecular mechanism by which a mechanical stimulus is translated into a chemical response in biological systems is still unclear. We show that mechanical stretching of single cytoplasmic proteins can activate binding of other molecules. We used magnetic tweezers, total internal reflection fluorescence, and atomic force microscopy to investigate the effect of force on the interaction between talin, a protein that links liganded membrane integrins to the cytoskeleton, and vinculin, a focal… CONTINUE READING
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