Stretching increases calcium influx and efflux in cultured pulmonary arterial smooth muscle cells.

@article{Bialecki1992StretchingIC,
  title={Stretching increases calcium influx and efflux in cultured pulmonary arterial smooth muscle cells.},
  author={Russell A Bialecki and Thomas J Kulik and Wilson Steven Colucci},
  journal={The American journal of physiology},
  year={1992},
  volume={263 5 Pt 1},
  pages={L602-6}
}
To determine the effect of a single static stretch on calcium fluxes in cultured pulmonary arterial smooth muscle cells (PASMC), calcium influx and efflux were evaluated in PASMC on a collagen-coated silicone membrane using 45Ca2+ as a tracer. A single 20% linear stretch of the silicone membrane of 1 min in duration increased calcium uptake by 71%. This effect was partially inhibited by verapamil or gadolinium, but was not altered by staurosporine, pertussis toxin, or removal of extracellular… CONTINUE READING

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