Stretching chromatin through confinement.

  title={Stretching chromatin through confinement.},
  author={Diana E Streng and Shuang Fang Lim and Junhan Pan and Alena Karpusenka and Robert Riehn},
  journal={Lab on a chip},
  volume={9 19},
We present a method for the stretching of chromatin molecules in nanofluidic channels width a cross-section of about 80 x 80 nm(2), and hundreds of microns long. The stretching of chromatin to about 12 basepairs/nm enables location-resolved optical investigation of the nucleic material with a resolution of up to 6 kbp. The stretching is based on the… CONTINUE READING