Stretch-inducible expression of the angiogenic factor CCN1 in vascular smooth muscle cells is mediated by Egr-1.

@article{Grote2004StretchinducibleEO,
  title={Stretch-inducible expression of the angiogenic factor CCN1 in vascular smooth muscle cells is mediated by Egr-1.},
  author={K. H. Grote and Udo Bavendiek and Christina Grothusen and Inna Flach and Denise Hilfiker-Kleiner and Helmut Drexler and Bernhard Schieffer},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 53},
  pages={55675-81}
}
CCN1 is an angiogenic factor that promotes cell adhesion, proliferation, and differentiation. CCN1-deficient mice suffer embryonic death because of vascular defects, demonstrating that CCN1 is required for vessel development. Because mechanical stretch may act as a trigger for vessel development, we investigated the impact of mechanical stretch on the regulatory mechanism of CCN1 expression. Mechanical stretch rapidly enhances CCN1 expression and release in vascular smooth muscle cells (VSMC… CONTINUE READING
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