Stretch-induced changes in heart rate and rhythm: clinical observations, experiments and mathematical models.

@article{Kohl1999StretchinducedCI,
  title={Stretch-induced changes in heart rate and rhythm: clinical observations, experiments and mathematical models.},
  author={Peter Kohl and Peter Hunter and Denis Noble},
  journal={Progress in biophysics and molecular biology},
  year={1999},
  volume={71 1},
  pages={91-138}
}
Clinical and research data indicate that active and passive changes in the mechanical environment of the heart are capable of influencing both the initiation and the spread of cardiac excitation via pathways that are intrinsic to the heart. This direction of the cross-talk between cardiac electrical and mechanical activity is referred to as mechano-electric feedback (MEF). MEF is thought to be involved in the adjustment of heart rate to changes in mechanical load and would help to explain the… CONTINUE READING

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