Stretch-induced alkalinization of feline papillary muscle: an autocrine-paracrine system.

@article{Cingolani1998StretchinducedAO,
  title={Stretch-induced alkalinization of feline papillary muscle: an autocrine-paracrine system.},
  author={Horacio Eugenio Cingolani and Bernardo V. Alvarez and I L Ennis and Mar{\'i}a Cristina Camili{\'o}n de Hurtado},
  journal={Circulation research},
  year={1998},
  volume={83 8},
  pages={775-80}
}
Myocardial stretch is a well-known stimulus that leads to hypertrophy. Little is known, however, about the intracellular pathways involved in the transmission of myocardial stretch to the cytoplasm and nucleus. Studies in neonatal cardiomyocytes demonstrated stretch-induced release of angiotensin II (Ang II). Because intracellular alkalinization is a signal to cell growth and Ang II stimulates the Na+/H+ exchanger (NHE), we studied the relationship between myocardial stretch and intracellular… CONTINUE READING