Stretch-induced actin remodeling requires targeting of zyxin to stress fibers and recruitment of actin regulators

@inproceedings{Hoffman2012StretchinducedAR,
  title={Stretch-induced actin remodeling requires targeting of zyxin to stress fibers and recruitment of actin regulators},
  author={Laura M. Hoffman and Christopher C. Jensen and Aashi Chaturvedi and Masaaki Yoshigi and Mary C Beckerle},
  booktitle={Molecular biology of the cell},
  year={2012}
}
Reinforcement of actin stress fibers in response to mechanical stimulation depends on a posttranslational mechanism that requires the LIM protein zyxin. The C-terminal LIM region of zyxin directs the force-sensitive accumulation of zyxin on actin stress fibers. The N-terminal region of zyxin promotes actin reinforcement even when Rho kinase is inhibited. The mechanosensitive integrin effector p130Cas binds zyxin but is not required for mitogen-activated protein kinase-dependent zyxin… CONTINUE READING
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