Stretch force on vascular smooth muscle cells enhances oxidation of LDL via superoxide production.

@article{Inoue1998StretchFO,
  title={Stretch force on vascular smooth muscle cells enhances oxidation of LDL via superoxide production.},
  author={Nobuhiro Inoue and Seinosuke Kawashima and K i Hirata and Yoshiyuki Rikitake and Saori Takeshita and Wataru Yamochi and Hozuka Akita and Masayoshi Yokoyama},
  journal={The American journal of physiology},
  year={1998},
  volume={274 6},
  pages={
          H1928-32
        }
}
Hemodynamic forces on vasculature profoundly influence atherogenesis. We examined the effect of stretch force on the oxidation of low-density lipoprotein (LDL) by rat aortic smooth muscle cells (RASM) and superoxide production. Stretch force was imposed on RASM cultured on deformable dishes by stretching the dishes. Incubation of native LDL with static RASM for 24 h resulted in LDL oxidation as indicated by increases in thiobarbituric acid-reacting substances from 9.5 +/- 2.3 to 24.5 +/- 2.3… CONTINUE READING

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