Stretch-dependent slow force response in isolated rabbit myocardium is Na+ dependent.

@article{Lewinski2003StretchdependentSF,
  title={Stretch-dependent slow force response in isolated rabbit myocardium is Na+ dependent.},
  author={Dirk von Lewinski and Burkhard Stumme and Lars Siegfried Maier and Claus Luers and Donald M. Bers and Burkert Pieske},
  journal={Cardiovascular research},
  year={2003},
  volume={57 4},
  pages={1052-61}
}
OBJECTIVE Stretch induces functional and trophic effects in mammalian myocardium via various signal transduction pathways. We tested stretch signal transduction on immediate and slow force response (SFR) in rabbit myocardium. METHODS Experiments were performed in isolated right ventricular muscles from adult rabbit hearts (37 degrees C, 1 Hz stimulation rate, bicarbonate-buffer). Muscles were rapidly stretched from 88% of optimal length (L88) to near optimal length (L98) for functional… CONTINUE READING