Stretch-dependent modulation of [Na+]i, [Ca2+]i, and pHi in rabbit myocardium--a mechanism for the slow force response.

@article{Luers2005StretchdependentMO,
  title={Stretch-dependent modulation of [Na+]i, [Ca2+]i, and pHi in rabbit myocardium--a mechanism for the slow force response.},
  author={Claus Luers and Florian Fialka and Andreas Elgner and Danan Zhu and Jens Kockskaemper and Dirk von Lewinski and Burkert Pieske},
  journal={Cardiovascular research},
  year={2005},
  volume={68 3},
  pages={454-63}
}
OBJECTIVE Rabbit ventricular myocardium is characterized by a biphasic response to stretch with an initial, rapid increase in force followed by a delayed, slow increase in force (slow force response, SFR). The initial phase is attributed to increased myofilament Ca(2+) sensitivity, but the mechanisms of the delayed phase are only incompletely understood. We tested whether stretch-dependent stimulation of Na(+)/H(+) exchange (NHE1) and consecutive changes in pH(i) and/or [Na(+)](i) may underlie… CONTINUE READING