Stretch activates heparin-binding EGF-like growth factor expression in bladder smooth muscle cells.

@article{Park1998StretchAH,
  title={Stretch activates heparin-binding EGF-like growth factor expression in bladder smooth muscle cells.},
  author={John M. Park and J. Borer and M. Freeman and C. Peters},
  journal={American journal of physiology. Cell physiology},
  year={1998},
  volume={275 5},
  pages={C1247-C1254}
}
Cultured rat bladder smooth muscle cells (SMC) were grown on collagen-coated silicone membranes and subjected to continuous cycles of stretch-relaxation. Semiquantitative RT-PCR analysis revealed a time-dependent increase in heparin-binding epidermal growth factor (EGF)-like growth factor (HB-EGF) mRNA levels after stretch, with maximal levels appearing after 4 h. Immunostaining for proHB-EGF revealed higher levels of HB-EGF protein in the stretched than in the nonstretched SMC. The ANG II… Expand
AP-1 mediates stretch-induced expression of HB-EGF in bladder smooth muscle cells.
TLDR
Findings indicate that AP-1-mediated transcription plays an important role in the regulation of gene expression in bladder muscle in response to mechanical forces. Expand
AP-1 mediates stretch-induced expression of HB-EGF in bladder smooth muscle cells.
TLDR
Findings indicate that AP-1-mediated transcription plays an important role in the regulation of gene expression in bladder muscle in response to mechanical forces. Expand
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Different stimuli, such as mechanical stretch and PDGF-BB, promote DNA synthesis in bladder SMC through shared downstream signaling pathways, and phenotypically similar cells from the bladder and heart show comparable pathway activation in response to stretch. Expand
The Effect of Heparin Binding Epidermal Growth Factor on the Hypertrophy / Hyperplasia of Human Bladder Smooth Muscle
Puropose: The bladder outlet obstruction (BOO) causes a bladder hypertrophy and/or hyperplasia with time. Heparin binding epidermal growth factor like growth factor (HB-EGF) is a potent mitogen forExpand
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Cyclic Stretch Promotes Proliferation and Contraction of Human Bladder Smooth Muscle Cells by Cajal-Mediated c-kit Expression in Interstitial Cells
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TLDR
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