Stretch-activated ion channels contribute to membrane depolarization after eccentric contractions.

  title={Stretch-activated ion channels contribute to membrane depolarization after eccentric contractions.},
  author={Todd A McBride and Brad Stockert and Fredric Gorin and Richard C. Carlsen},
  journal={Journal of applied physiology},
  volume={88 1},
We tested the hypothesis that eccentric contractions activate mechanosensitive or stretch-activated ion channels (SAC) in skeletal muscles, producing increased cation conductance. Resting membrane potentials and contractile function were measured in rat tibialis anterior muscles after single or multiple exposures to a series of eccentric contractions. Each exposure produced a significant and prolonged (>24 h) membrane depolarization in exercised muscle fibers. The magnitude and duration of the… CONTINUE READING
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