Stretch-activated channel Piezo1 is up-regulated in failure heart and cardiomyocyte stimulated by AngII.

Abstract

Mechanotransduction is the conversion of extracellular mechanical stimuli into intracellular biochemical signals, and plays an important role in heart responses to its own mechanical environment. Piezo1 as a distinct stretch-activated channel (SAC) in mammal involves in not only vascular remodeling during embryonic development but also arterial remodeling… (More)

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