Stretch-activated cation channel TRPV4 mediates hyposmotically induced prolactin release from prolactin cells of mozambique tilapia Oreochromis mossambicus.

@article{Watanabe2012StretchactivatedCC,
  title={Stretch-activated cation channel TRPV4 mediates hyposmotically induced prolactin release from prolactin cells of mozambique tilapia Oreochromis mossambicus.},
  author={Soichi Watanabe and André P. Seale and E. Gordon Grau and Toyoji Kaneko},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  year={2012},
  volume={302 8},
  pages={
          R1004-11
        }
}
In teleost fish, prolactin (PRL) is an important hormone for hyperosmoregulation. The release of PRL from the pituitary of Mozambique tilapia is stimulated by a decrease in extracellular osmolality. Previous studies have shown that hyposmotically induced PRL release is linked with cell volume changes, and that stretch-activated Ca(2+) channels are likely responsible for the initiation of the signal transduction for PRL release. In this study, we identified the stretch-activated Ca(2+) channel… CONTINUE READING
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