Stretch-Sensitive Down-Regulation of the miR-144/451 Cluster in Vascular Smooth Muscle and Its Role in AMP-Activated Protein Kinase Signaling

@inproceedings{Turczyska2013StretchSensitiveDO,
  title={Stretch-Sensitive Down-Regulation of the miR-144/451 Cluster in Vascular Smooth Muscle and Its Role in AMP-Activated Protein Kinase Signaling},
  author={Karolina M. Turczyńska and Anirban Bhattachariya and Johanna S{\"a}ll and Olga G{\"o}ransson and Karl Sw{\"a}rd and Per Hellstrand and Sebastian Albinsson},
  booktitle={PloS one},
  year={2013}
}
Vascular smooth muscle cells are constantly exposed to mechanical force by the blood pressure, which is thought to regulate smooth muscle growth, differentiation and contractile function. We have previously shown that the expression of microRNAs (miRNAs), small non-coding RNAs, is essential for regulation of smooth muscle phenotype including stretch-dependent contractile differentiation. In this study, we have investigated the effect of mechanical stretch on miRNA expression and the role of… CONTINUE READING