Stretch‐stimulated glucose uptake in skeletal muscle is mediated by reactive oxygen species and p38 MAP‐kinase

  title={Stretch‐stimulated glucose uptake in skeletal muscle is mediated by reactive oxygen species and p38 MAP‐kinase},
  author={Melissa A. Chambers and Jennifer S. Moylan and J. Smith and L. Goodyear and M. Reid},
  journal={The Journal of Physiology},
  • Melissa A. Chambers, Jennifer S. Moylan, +2 authors M. Reid
  • Published 2009
  • Biology, Medicine
  • The Journal of Physiology
  • Alternatives to the canonical insulin‐stimulated pathway for glucose uptake are exercise‐ and exogenous reactive oxygen species (ROS)‐stimulated glucose uptake. We proposed a model wherein mechanical loading, i.e. stretch, stimulates production of ROS to activate AMP‐activated kinase (AMPK) to increase glucose uptake. Immunoblotting was used to measure protein phosphorylation; the fluorochrome probe 2′7′‐dichlorofluorescin diacetate was used to measure cytosolic oxidant activity and 2‐deoxy‐d[1… CONTINUE READING
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