Stressing the role of FoxO proteins in lifespan and disease

@article{Horst2007StressingTR,
  title={Stressing the role of FoxO proteins in lifespan and disease},
  author={Armando van der Horst and Boudewijn M. T. Burgering},
  journal={Nature Reviews Molecular Cell Biology},
  year={2007},
  volume={8},
  pages={440-450}
}
Members of the class O of forkhead box transcription factors (FoxO) have important roles in metabolism, cellular proliferation, stress tolerance and probably lifespan. The activity of FoxOs is tightly regulated by post-translational modifications, including phosphorylation, acetylation and ubiquitylation. Several of the enzymes that regulate the turnover of these post-translational modifications are shared between FoxO and p53. These regulatory enzymes affect FoxO and p53 function in an… 

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