Stressing the obvious? An allostatic look at critical illness.

  title={Stressing the obvious? An allostatic look at critical illness.},
  author={Aim{\'e}e L. Brame and Mervyn Singer},
  journal={Critical care medicine},
  volume={38 10 Suppl},
Stress plays a crucial role in coping with extrinsic insults through modulating the autonomic nervous system, the hypothalamic-pituitary-adrenal axis and the cardiovascular, metabolic, and immune systems. The allostatic model of maintaining "stability through change" allows the body to respond to a challenge by adjusting to a new steady-state and terminating it once the danger has passed. However, unrelenting stress can lead to decompensation with development of pathologic illness. With… CONTINUE READING
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