Stressful reactions and panic attacks induced by flumazenil in chronic benzodiazepine users

@article{Bernik1998StressfulRA,
  title={Stressful reactions and panic attacks induced by flumazenil in chronic benzodiazepine users},
  author={M. Bernik and C. Gorenstein and A. H. Vieira Filho},
  journal={Journal of Psychopharmacology},
  year={1998},
  volume={12},
  pages={146 - 150}
}
The acute effects of flumazenil, a benzodiazepine (BZD) receptor antagonist in long-term BZD users were used as a possible test to detect physiological dependence. Thirty-four subjects (20 females, 14 males) aged 26-48 years (mean ± SD, 42.4 ± 8.5 years), all chronic users of low doses of diazepam (5-20 mg/day,14.2 ± 4.8 mg/day) for 5 to 28 years (10.5 ± 6 years), received a single 1-mg i.v. flumazenil dose or saline, infused slowly under double-blind conditions. Physiological dependence was… Expand
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