Stressful manipulations that elevate corticosterone reduce blood-brain barrier permeability to pyridostigmine in the Rat.

@article{Sinton2000StressfulMT,
  title={Stressful manipulations that elevate corticosterone reduce blood-brain barrier permeability to pyridostigmine in the Rat.},
  author={Christopher M. Sinton and Thomas E. Fitch and Frederick Petty and Robert W. Haley},
  journal={Toxicology and applied pharmacology},
  year={2000},
  volume={165 1},
  pages={99-105}
}
Pyridostigmine bromide (PB), a reversible inhibitor of acetylcholinesterase (AChE), is used for the treatment of myasthenia gravis. PB has also been provided to military personnel for preexposure protection against potential soman release. The entry of PB into the brain is typically minimal, but recently published data in mice suggest that a brief forced swim stress increases the permeability of the blood-brain barrier to PB. From these results, PB administered under stressful conditions was… CONTINUE READING